Authors
Phil H Lee, Verneri Anttila, Hyejung Won, Yen-Chen A Feng, Jacob Rosenthal, Zhaozhong Zhu, Elliot M Tucker-Drob, Michel G Nivard, Andrew D Grotzinger, Danielle Posthuma, Meg M-J Wang, Dongmei Yu, Eli A Stahl, Raymond K Walters, Richard JL Anney, Laramie E Duncan, Tian Ge, Rolf Adolfsson, Tobias Banaschewski, Sintia Belangero, Edwin H Cook, Giovanni Coppola, Eske M Derks, Pieter J Hoekstra, Jaakko Kaprio, Anna Keski-Rahkonen, George Kirov, Henry R Kranzler, Jurjen J Luykx, Luis A Rohde, Clement C Zai, Esben Agerbo, MJ Arranz, Philip Asherson, Marie Bækvad-Hansen, Gísli Baldursson, Mark Bellgrove, Richard A Belliveau, Jan Buitelaar, Christie L Burton, Jonas Bybjerg-Grauholm, Miquel Casas, Felecia Cerrato, Kimberly Chambert, Claire Churchhouse, Bru Cormand, Jennifer Crosbie, Søren Dalsgaard, Ditte Demontis, Alysa E Doyle, Ashley Dumont, Josephine Elia, Jakob Grove, Olafur O Gudmundsson, Jan Haavik, Hakon Hakonarson, Christine S Hansen, Catharina A Hartman, Ziarih Hawi, Amaia Hervás, David M Hougaard, Daniel P Howrigan, Hailiang Huang, Jonna Kuntsi, Kate Langley, Klaus-Peter Lesch, Patrick WL Leung, Sandra K Loo, Joanna Martin, Alicia R Martin, James J McGough, Sarah E Medland, Jennifer L Moran, Ole Mors, Preben B Mortensen, Robert D Oades, Duncan S Palmer, Carsten B Pedersen, Marianne G Pedersen, Triinu Peters, Timothy Poterba, Jesper B Poulsen, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Aribert Rothenberger, Paula Rovira, Cristina Sánchez-Mora, F Kyle Satterstrom, Russell Schachar, Maria Soler Artigas, Stacy Steinberg, Hreinn Stefansson, Patrick Turley, G Bragi Walters, Thomas Werge, Tetyana Zayats, Dan E Arking, Francesco Bettella, Joseph D Buxbaum, Jane H Christensen, Ryan L Collins, Hilary Coon, Silvia De Rubeis, Richard Delorme, Dorothy E Grice, Thomas F Hansen, Peter A Holmans, Sigrun Hope, Christina M Hultman, Lambertus Klei, Christine Ladd-Acosta, Pall Magnusson, Terje Nærland, Mette Nyegaard, Dalila Pinto, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer Reichert, Kathryn Roeder, Guy A Rouleau, Evald Saemundsen, Stephan J Sanders, Sven Sandin, Beate St Pourcain, Kari Stefansson, James S Sutcliffe, Michael E Talkowski, Lauren A Weiss, A Jeremy Willsey, Ingrid Agartz, Huda Akil, Diego Albani, Martin Alda, Thomas D Als, Adebayo Anjorin, Lena Backlund, Nicholas Bass, Michael Bauer, Bernhard T Baune, Frank Bellivier, Sarah E Bergen, Wade H Berrettini, Joanna M Biernacka, Douglas HR Blackwood, Erlend Bøen, Monika Budde, William Bunney, Margit Burmeister
Publication date
2019/12/12
Journal
Cell
Volume
179
Issue
7
Pages
1469-1482. e11
Publisher
Elsevier
Description
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that …
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