Authors
Christos C Zouboulis, Andre Nogueira da Costa, E Makrantonaki, XX Hou, Daifallah Almansouri, JT Dudley, H Edwards, B Readhead, O Balthasar, Gregor B E Jemec, NG Bonitsis, Georgios Nikolakis, Dietrich Trebing, Konstantin C Zouboulis, Amir M Hossini
Publication date
2020/4
Journal
Journal of the European Academy of Dermatology and Venereology
Volume
34
Issue
4
Pages
846-861
Description
Background
The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease‐driving mechanisms and tissue targeting.
Objective
Robust characterization of the underlying HS mechanisms and detection of the involved skin compartments.
Methods
Hidradenitis suppurativa/acne inversa molecular taxonomy and key signalling pathways were studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non‐lesional skin obtained from female HS patients and matched healthy controls using the Agilent array platform. The differential gene expression was confirmed by quantitative real‐time PCR and targeted protein characterization via immunohistochemistry in another set of female patients. HS‐involved skin compartments were also recognized by immunohistochemistry.
Results
Alterations to key regulatory pathways …
Scholar articles
CC Zouboulis, A Nogueira da Costa, E Makrantonaki… - Journal of the European Academy of Dermatology and …, 2020