Authors
Abbie Saunders, Leighton J Core, John T Lis
Publication date
2006/8/1
Source
Nature reviews Molecular cell biology
Volume
7
Issue
8
Pages
557-567
Publisher
Nature Publishing Group UK
Description
Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many of these proteins regulate specific genes by targeting upstream promoter regions, whereas a smaller but mechanistically diverse set of factors functions at most genes during RNA polymerase II (Pol II) elongation. These elongation factors can affect mRNA production at particular stages and in different ways during transcription. Some factors act directly on Pol II, whereas others manipulate the chromatin environment.
Total citations
Scholar articles
A Saunders, LJ Core, JT Lis - Nature reviews Molecular cell biology, 2006