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It is now over 40 years since it was first hypothesized that emotions could influence immunity and disease (Ader et al., 1987; Solomon and Moos, 1964). Since then, reliable associations have been found between immune function and depression, stress, and anxiety (see reviews by Herbert and Cohen, 1993a, 1993b; Segerstrom and Miller, 2004). In contrast, there has been little work on the effects of positive emotions on immunity and immune-mediated disease (Pressman and Cohen, 2005). Indeed, a search of PsycINFO revealed almost 100 times more studies on “depression and immunity" than there are on “happiness and immunity." The goal of this chapter is to review evidence for a relationship between positive emotions and immune function, and to explore the implications of this connection for health.