Authors
PETER J McCARTHY, PETER F TROKE, KEITH GULL
Publication date
1985/4
Journal
Microbiology
Volume
131
Issue
4
Pages
775-780
Publisher
Microbiology Society
Description
Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki = 0·16 μm (0·1 μg ml–l)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of C. albicans resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.
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Scholar articles
PJ McCARTHY, PF TROKE, K GULL - Microbiology, 1985