Authors
Sarath P Gunasekera, Peter J McCarthy, Ross E Longley, Shirley A Pomponi, Amy E Wright, Emil Lobkovsky, Jon Clardy
Publication date
1999/1/22
Journal
Journal of natural products
Volume
62
Issue
1
Pages
173-175
Publisher
American Chemical Society
Description
Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.
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Scholar articles
SP Gunasekera, PJ McCarthy, RE Longley… - Journal of natural products, 1999