Authors
Peter M Visscher, Matthew A Brown, Mark I McCarthy, Jian Yang
Publication date
2012/1/13
Journal
The American Journal of Human Genetics
Volume
90
Issue
1
Pages
7-24
Publisher
Cell Press
Description
The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide polymorphisms (SNPs) and common diseases such as heart disease, diabetes, auto-immune diseases, and psychiatric disorders. We start by giving a number of quotes from scientists and journalists about perceived problems with GWASs. We will then briefly give the history of GWASs and focus on the discoveries made through this experimental design, what those discoveries tell us and do not tell us about the genetics and biology of complex traits, and what immediate utility has come out of these studies. Rather than giving an exhaustive review of all reported …
Total citations
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Scholar articles
PM Visscher, MA Brown, MI McCarthy, J Yang - The American Journal of Human Genetics, 2012