Authors
Nedenia Bonvino Stafuzza, Rafael Medeiros de Oliveira Silva, Breno de Oliveira Fragomeni, Yutaka Masuda, Yijian Huang, Kent Gray, Daniela A Lino Lourenco
Publication date
2019/12
Journal
BMC genomics
Volume
20
Pages
1-11
Publisher
BioMed Central
Description
Background
In this study we integrated the CNV (copy number variation) and WssGWAS (weighted single-step approach for genome-wide association) analyses to increase the knowledge about number of piglets born alive, an economically important reproductive trait with significant impact on production efficiency of pigs.
Results
A total of 3892 samples were genotyped with the Porcine SNP80 BeadChip. After quality control, a total of 57,962 high-quality SNPs from 3520 Duroc pigs were retained. The PennCNV algorithm identified 46,118 CNVs, which were aggregated by overlapping in 425 CNV regions (CNVRs) ranging from 2.5 Kb to 9718.4 Kb and covering 197 Mb (~ 7.01%) of the pig autosomal genome. The WssGWAS identified 16 genomic regions explaining more than 1% of the additive genetic variance for number of piglets born alive. The …
Scholar articles
NB Stafuzza, RMO Silva, BO Fragomeni, Y Masuda… - BMC genomics, 2019