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In the last few years, the trend in health care of embracing artificial intelligence (AI) has dramatically changed the medical landscape. Medical centres have adopted AI applications to increase the accuracy of disease diagnosis and mitigate health risks. AI applications have changed rules and policies related to healthcare practice and work ethics. However, building trustworthy and explainable AI (XAI) in healthcare systems is still in its early stages. Specifically, the European Union has stated that AI must be human-centred and trustworthy, whereas in the healthcare sector, low methodological quality and high bias risk have become major concerns. This study endeavours to offer a systematic review of the trustworthiness and explainability of AI applications in healthcare, incorporating the assessment of quality, bias risk, and data fusion to supplement previous studies and provide more accurate and definitive findings …