Authors
Andrew J Davidson, Neil S Morton, Sarah J Arnup, Jurgen C De Graaff, Nicola Disma, Davinia E Withington, Geoff Frawley, Rodney W Hunt, Pollyanna Hardy, Magda Khotcholava, Britta S von Ungern Sternberg, Niall Wilton, Pietro Tuo, Ida Salvo, Gillian Ormond, Robyn Stargatt, Bruno Guido Locatelli, Mary Ellen McCann, General Anesthesia compared to Spinal anesthesia (GAS) Consortium
Publication date
2015/7/1
Journal
Anesthesiology
Volume
123
Issue
1
Pages
38-54
Description
Background
Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia.
Methods
Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded.
Results
Three hundred sixty-three patients were assigned to RA and 359 to GA …
Scholar articles
AJ Davidson, NS Morton, SJ Arnup, JC De Graaff… - Anesthesiology, 2015