Authors
Kristin M Poole, Christopher E Nelson, Rucha V Joshi, John R Martin, Mukesh K Gupta, Skylar C Haws, Taylor E Kavanaugh, Melissa C Skala, Craig L Duvall
Publication date
2015/2/1
Journal
Biomaterials
Volume
41
Pages
166-175
Publisher
Elsevier
Description
A new microparticle-based delivery system was synthesized from reactive oxygen species (ROS)-responsive poly(propylene sulfide) (PPS) and tested for “on demand” antioxidant therapy. PPS is hydrophobic but undergoes a phase change to become hydrophilic upon oxidation and thus provides a useful platform for ROS-demanded drug release. This platform was tested for delivery of the promising anti-inflammatory and antioxidant therapeutic molecule curcumin, which is currently limited in use in its free form due to poor pharmacokinetic properties. PPS microspheres efficiently encapsulated curcumin through oil-in-water emulsion and provided sustained, on demand release that was modulated in vitro by hydrogen peroxide concentration. The cytocompatible, curcumin-loaded microspheres preferentially targeted and scavenged intracellular ROS in activated macrophages, reduced in vitro cell death in the …
Scholar articles
KM Poole, CE Nelson, RV Joshi, JR Martin, MK Gupta… - Biomaterials, 2015