Authors
Stanley J Szefler, Brenda R Phillips, Fernando D Martinez, Vernon M Chinchilli, Robert F Lemanske Jr, Robert C Strunk, Robert S Zeiger, Gary Larsen, Joseph D Spahn, Leonard B Bacharier, Gordon R Bloomberg, Theresa W Guilbert, Gregory Heldt, Wayne J Morgan, Mark H Moss, Christine A Sorkness, Lynn M Taussig
Publication date
2005/2/1
Journal
Journal of Allergy and Clinical Immunology
Volume
115
Issue
2
Pages
233-242
Publisher
Mosby
Description
BACKGROUND
Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients.
OBJECTIVE
We sought to determine whether responses to ICSs and LTRAs are concordant for individuals or whether asthmatic patients who do not respond to one medication respond to the other.
METHODS
Children 6 to 17 years of age with mild-to-moderate persistent asthma were randomized to one of 2 crossover sequences, including 8 weeks of an ICS, fluticasone propionate (100 μg twice daily), and 8 weeks of an LTRA, montelukast (5-10 mg nightly depending on age), in a multicenter, double-masked, 18-week trial. Response was assessed on the basis of improvement in FEV1 and assessed for relationships to baseline asthma phenotype-associated biomarkers.
RESULTS
Defining response as improvement in FEV1 of 7.5% or greater, 17% of 126 participants …
Total citations
Scholar articles
SJ Szefler, BR Phillips, FD Martinez, VM Chinchilli… - Journal of Allergy and Clinical Immunology, 2005