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Related US Application Data Primary Examiner—Brian Whiteman (60) Division of application No. 13/971,662, filed on Aug.(74) Attorney, Agent, or Firm—Medlen & Carroll, LLP

20, 2013, now Pat. No. 9,095,592, which is a (57) ABSTRACT continuation-in-part of application No. 13/330,062,-0 filed on Dec. 19, 2011, now Pat. No. 8,513,212, which Receptor protein kinases (RPTKs) transmit extracellular is a continuation of application No. 12/613,937, filed signals across the plasma membrane to cytosolic proteins, on Nov. 6, 2009, now abandoned. stimulating formation of complexes that regulate key cellu lar functions. Over half of the known tyrosine kinases are (60) Provisional application No. 61/112,406, filed on Nov. implicated in human cancers and are therefore highly prom 7, 2008. ising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically (51) Int. Cl …