Authors
Sevahn K Vorperian, Mira N Moufarrej, Tabula Sapiens Consortium Overall Project Direction and Coordination Jones Robert C. 3 Karkanias Jim 6 Krasnow Mark 7 8 Pisco Angela Oliveira 6 Quake Stephen R. 3 4 6 Salzman Julia 7 9 Yosef Nir 6 10 11 12, Donor Recruitment Bulthaup Bryan 13 Brown Phillip 13 Harper William 13 Hemenez Marisa 13 Ponnusamy Ravikumar 13 Salehi Ahmad 13 Sanagavarapu Bhavani A. 13 Spallino Eileen 13, Surgeons Aaron Ksenia A. 14 Concepcion Waldo 13 Gardner James M. 15 16 Kelly Burnett 13 17 Neidlinger Nikole 13 Wang Zifa 13, Logistical coordination Crasta Sheela 3 6 Kolluru Saroja 3 6 Morri Maurizio 6 Tan Serena Y. 18 Travaglini Kyle J. 7 Xu Chenling 10, Sequencing Detweiler Angela M. 6 Mekonen Honey 6 Neff Norma F. 6 Sit Rene V. 6 Tan Michelle 6 Yan Jia 6, Histology Bean Gregory R. 18 Charu Vivek 18 Forgó Erna 18 Martin Brock A. 18 Ozawa Michael G. 18 Silva Oscar 18 Toland Angus 18 Vemuri Venkata NP 6, Expert Cell Type Annotation Culver Rebecca 28 Dethlefsen Les 46 Ho Po-Yi 19 Liu Shixuan 7 43 Maltzman Jonathan S. 47 48 Metzger Ross J. 30 49 Sasagawa Koki 22 Sinha Rahul 18 21 38 Song Hanbing 41 Wang Bruce 23
Publication date
2022/6
Journal
Nature biotechnology
Volume
40
Issue
6
Pages
855-861
Publisher
Nature Publishing Group US
Description
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.
Total citations
Scholar articles
SK Vorperian, MN Moufarrej… - Nature biotechnology, 2022