Authors
University of California, San Francisco MS‐EPIC Team, Bruce AC Cree, Jill A Hollenbach, Riley Bove, Gina Kirkish, Simone Sacco, Eduardo Caverzasi, Antje Bischof, Tristan Gundel, Alyssa H Zhu, Nico Papinutto, William A Stern, Carolyn Bevan, Andrew Romeo, Douglas S Goodin, Jeffrey M Gelfand, Jennifer Graves, Ari J Green, Michael R Wilson, Scott S Zamvil, Chao Zhao, Refujia Gomez, Nicholas R Ragan, Gillian Q Rush, Patrick Barba, Adam Santaniello, Sergio E Baranzini, Jorge R Oksenberg, Roland G Henry, Stephen L Hauser
Publication date
2019/5
Journal
Annals of neurology
Volume
85
Issue
5
Pages
653-666
Publisher
John Wiley & Sons, Inc.
Description
Objective
Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared to natural history studies from the pretreatment era. Nonetheless, in our recently reported prospective cohort, more than half of patients with relapsing MS accumulated significant new disability by the 10th year of follow‐up. Notably, “no evidence of disease activity” at 2 years did not predict long‐term stability. Here, we determined to what extent clinical relapses and radiographic evidence of disease activity contribute to long‐term disability accumulation.
Methods
Disability progression was defined as an increase in Expanded Disability Status Scale (EDSS) of 1.5, 1.0, or 0.5 (or greater) from baseline EDSS = 0, 1.0–5.0, and 5.5 or higher, respectively, assessed from baseline to year 5 (±1 year) and sustained to year 10 (±1 year). Longitudinal analysis of …
Total citations
201920202021202220232024133571797351
Scholar articles
University of California, San Francisco MS‐EPIC Team… - Annals of neurology, 2019