Authors
University of California, San Francisco MS‐EPIC Team:, Bruce AC Cree, Pierre‐Antoine Gourraud, Jorge R Oksenberg, Carolyn Bevan, Elizabeth Crabtree‐Hartman, Jeffrey M Gelfand, Douglas S Goodin, Jennifer Graves, Ari J Green, Ellen Mowry, Darin T Okuda, Daniel Pelletier, H‐Christian von Büdingen, Scott S Zamvil, Alisha Agrawal, Stacy Caillier, Caroline Ciocca, Refujia Gomez, Rachel Kanner, Robin Lincoln, Antoine Lizee, Pamela Qualley, Adam Santaniello, Leena Suleiman, Monica Bucci, Valentina Panara, Nico Papinutto, William A Stern, Alyssa H Zhu, Gary R Cutter, Sergio Baranzini, Roland G Henry, Stephen L Hauser
Publication date
2016/10
Journal
Annals of neurology
Volume
80
Issue
4
Pages
499-510
Description
Objective
To characterize the accrual of long‐term disability in a cohort of actively treated multiple sclerosis (MS) patients and to assess whether clinical and magnetic resonance imaging (MRI) data used in clinical trials have long‐term prognostic value.
Methods
This is a prospective study of 517 actively managed MS patients enrolled at a single center.
Results
More than 91% of patients were retained, with data ascertained up to 10 years after the baseline visit. At this last assessment, neurologic disability as measured by the Expanded Disability Status Scale (EDSS) was stable or improved compared to baseline in 41% of patients. Subjects with no evidence of disease activity (NEDA) by clinical and MRI criteria during the first 2 years had long‐term outcomes that were no different from those of the cohort as a whole. 25‐OH vitamin D serum levels were inversely associated with short‐term MS disease activity …
Scholar articles
University of California, San Francisco MS‐EPIC Team:… - Annals of neurology, 2016