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Heavy alcohol use frequently co-occurs with cigarette smoking and may impede smoking cessation. This clinical trial examined whether smoking cessation treatment that incorporates brief alcohol intervention can improve smoking cessation outcomes (7-day verified point prevalence abstinence) and reduce drinks consumed per week. Heavy drinkers seeking smoking cessation treatment were assigned by urn randomization to receive, along with 8 weeks of nicotine replacement therapy, either a 4-session standard smoking cessation treatment (ST, n= 119) or standard treatment of equal intensity that incorporated brief alcohol intervention (ST-BI, n= 117). Across follow-ups over 26 weeks, participants in ST-BI reported approximately 20% fewer drinks per week (p<. 027) and greater smoking abstinence (adjusted odds ratio= 1.56; 95% confidence interval= 1.01, 2.43) than did those in ST; however, effects on smoking …