Authors
Marjolein J Peters, Roby Joehanes, Luke C Pilling, Claudia Schurmann, Karen N Conneely, Joseph Powell, Eva Reinmaa, George L Sutphin, Alexandra Zhernakova, Katharina Schramm, Yana A Wilson, Sayuko Kobes, Taru Tukiainen, Yolande F Ramos, Harald HH Göring, Myriam Fornage, Yongmei Liu, Sina A Gharib, Barbara E Stranger, Philip L De Jager, Abraham Aviv, Daniel Levy, Joanne M Murabito, Peter J Munson, Tianxiao Huan, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Jeroen Van Rooij, Lisette Stolk, Linda Broer, Michael MPJ Verbiest, Mila Jhamai, Pascal Arp, Andres Metspalu, Liina Tserel, Lili Milani, Nilesh J Samani, Pärt Peterson, Silva Kasela, Veryan Codd, Annette Peters, Cavin K Ward-Caviness, Christian Herder, Melanie Waldenberger, Michael Roden, Paula Singmann, Sonja Zeilinger, Thomas Illig, Georg Homuth, Hans-Jörgen Grabe, Henry Völzke, Leif Steil, Thomas Kocher, Anna Murray, David Melzer, Hanieh Yaghootkar, Stefania Bandinelli, Eric K Moses, Jack W Kent, Joanne E Curran, Matthew P Johnson, Sarah Williams-Blangero, Harm-Jan Westra, Allan F McRae, Jennifer A Smith, Sharon LR Kardia, Iiris Hovatta, Markus Perola, Samuli Ripatti, Veikko Salomaa, Anjali K Henders, Nicholas G Martin, Alicia K Smith, Divya Mehta, Elisabeth B Binder, K Maria Nylocks, Elizabeth M Kennedy, Torsten Klengel, Jingzhong Ding, Astrid M Suchy-Dicey, Daniel A Enquobahrie, Jennifer Brody, Jerome I Rotter, Yii-Der I Chen, Jeanine Houwing-Duistermaat, Margreet Kloppenburg, P Eline Slagboom, Quinta Helmer, Wouter Den Hollander, Shannon Bean, Towfique Raj, Noman Bakhshi, Qiao Ping Wang, Lisa J Oyston, Bruce M Psaty, Russell P Tracy, Grant W Montgomery, Stephen T Turner, John Blangero, Ingrid Meulenbelt, Kerry J Ressler, Jian Yang, Lude Franke, Johannes Kettunen, Peter M Visscher, G Gregory Neely, Ron Korstanje, Robert L Hanson, Holger Prokisch, Luigi Ferrucci, Tonu Esko, Alexander Teumer, Joyce BJ Van Meurs, Andrew D Johnson
Publication date
2015/10/22
Journal
Nature communications
Volume
6
Issue
1
Pages
1-14
Publisher
Nature Publishing Group
Description
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age’of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood …
Scholar articles
MJ Peters, R Joehanes, LC Pilling, C Schurmann… - Nature communications, 2015