Authors
Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tonu Esko, David M Evans, Mario Falchi, Mary F Feitosa, Teresa Ferreira, Åsa K Hedman, Robin Haring, Pirro G Hysi, Mark M Iles, Anne E Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John RB Perry, Tune H Pers, Qibin Qi, Marianna Sanna, Ellen M Schmidt, William R Scott, Dmitry Shungin, Alexander Teumer, Anna AE Vinkhuyzen, Ryan W Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan JL Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S Buchman, Tommy Cederholm, Audrey C Choh, Hyung Jin Choi, Joanne E Curran, Lisette CPGM De Groot, Philip L De Jager, Rosalie AM Dhonukshe-Rutten, Anke W Enneman, Elodie Eury, Daniel S Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E Garcia, Simone Gärtner, Bok-Ghee Han, Aki S Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G Lee, Jong-Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo-Pekka Lyytikäinen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A Nalls, Carrie M Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin MA Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie Van Der Velde, Natasja M Van Schoor, Niek Verweij, Alan F Wright, Lei Yu, Joseph M Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D Palmer, Janina S Ried, Robert A Scott, Alena Stancakova, Peter J Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P Kiel, Brigitte Kühnel, Massimo Mangino, Barbara Mcknight, Cristina Menni, Jeffrey R O'Connell, Ben A Oostra, Alan R Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M Van Duijn, Peter Vollenweider, Charles C White, Michael Boehnke, Yvonne Boettcher, Richard S Cooper, Nita G Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimaki, Meena Kumari
Publication date
2016/2/1
Journal
Nature communications
Volume
7
Issue
1
Pages
10495
Publisher
Nature Publishing Group UK
Description
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Scholar articles
Y Lu, FR Day, S Gustafsson, ML Buchkovich, J Na… - Nature communications, 2016