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Climate change is a major concern in wheat agroecosystems as it can affect productivity and crop water use. This study used the AquaCrop model to evaluate climate change impacts on the wheat yield, crop water use and water footprint of wheat production in the Middle-Manyame sub-catchment of Zimbabwe. Climate scenarios were based on simulations from the NCC-NorESM1-M, CCCma-CanESM2 and MOHC-HadGEM2-ES General Climate Models downscaled using three Regional Climate Models (RCA4, RegCM4 and CRCM5) under two Representative Concentration Pathways (RCP4.5 and RCP8.5). The results showed that, compared to the baseline climate (1980–2010), yield may increase by 22.60, 29.47 27.80, and 53.85% for the RCP4.5 2040 s, RCP4.5 2080 s, RCP8.5 2040 s and RCP8.5 2080 s scenarios, respectively. Crop water use may decrease by 1.68, 1.25, 3.7 and 6.47%, respectively …