Authors
Tiago Q Faria, Ana Mingote, Filipa Siopa, Rita Ventura, Christopher Maycock, Helena Santos
Publication date
2008/12/8
Journal
Carbohydrate research
Volume
343
Issue
18
Pages
3025-3033
Publisher
Elsevier
Description
In response to stressful conditions like supra-optimal salinity in the growth medium or temperature, many microorganisms accumulate low-molecular-mass organic compounds known as compatible solutes. In contrast with mesophiles that accumulate neutral or zwitterionic compounds, the solutes of hyperthermophiles are typically negatively charged. (2R)-2-(α-d-Mannopyranosyl)glycerate (herein abbreviated as mannosylglycerate) is one of the most widespread solutes among thermophilic and hyperthermophilic prokaryotes. In this work, several molecules chemically related to mannosylglycerate were synthesized, namely (2S)-2-(1-O-α-d-mannopyranosyl)propionate, 2-(1-O-α-d-mannopyranosyl)acetate, (2R)-2-(1-O-α-d-glucopyranosyl)glycerate and 1-O-(2-glyceryl)-α-d-mannopyranoside. The effectiveness of the newly synthesized compounds for the protection of model enzymes against heat-induced …
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TQ Faria, A Mingote, F Siopa, R Ventura, C Maycock… - Carbohydrate research, 2008