Authors
Fayssal M Farahat, Corie A Ellison, Matthew R Bonner, Barbara P McGarrigle, Alice L Crane, Richard A Fenske, Michael R Lasarev, Diane S Rohlman, W Kent Anger, Pamela J Lein, James R Olson
Publication date
2011/6
Journal
Environmental health perspectives
Volume
119
Issue
6
Pages
801-806
Publisher
National Institute of Environmental Health Sciences
Description
Background
Chlorpyrifos (CPF), a widely used organophosphorus pesticide (OP), is metabolized to CPF-oxon, a potent cholinesterase (ChE) inhibitor, and trichloro-2-pyridinol (TCPy). Urinary TCPy is often used as a biomarker for CPF exposure, whereas blood ChE activity is considered an indicator of CPF toxicity. However, whether these biomarkers are dose related has not been studied extensively in populations with repeated daily OP exposures.
Objective
We sought to determine the relationship between blood ChE and urinary TCPy during repeated occupational exposures to CPF.
Methods
Daily urine samples and weekly blood samples were collected from pesticide workers (n = 38) in Menoufia Governorate, Egypt, before, during, and after 9–17 consecutive days of CPF application to cotton fields. We compared blood butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) activities with the respective …
Total citations
Scholar articles
FM Farahat, CA Ellison, MR Bonner, BP McGarrigle… - Environmental health perspectives, 2011