Authors
C Rogier, AB Ly, A Tall, B Cisse, Jean-François Trape
Publication date
1999/3
Journal
The American journal of tropical medicine and hygiene
Volume
60
Issue
3
Pages
410-420
Description
Six hundred eighty-nine Plasmodium falciparum malaria attacks were observed during a three-year period among 226 inhabitants of the village of Dielmo, Senegal, an area of high malaria transmission. Malaria attacks were defined as clinical episodes with fever (body temperature 38.0 C) or reporting of fever or headache or vomiting, associated with a parasite: leukocyte ratio above an age-dependent pyrogenic threshold identified in this population. The symptom frequencies were tested against age, gender, and parasite density using a random-effect logistic regression model and the study of distinguishable clinical presentations was carried out by multi-correspondence analysis. There was little difference between the severity of symptoms during the initial course of attacks in young children and adults, and this severity was not correlated with the duration of the pathologic episode. It was not possible to distinguish objectively different malaria attack types according to the severity of clinical manifestations. In contrast, the duration of fever, symptoms, and parasite clearance were significantly longer among the youngest children than among the oldest children and adults. These findings suggest that of the two components of protective immunity, anti-parasite immunity and anti-toxic immunity, only the first would play a major role as age increases. They suggest also that the initial clinical presentation of malaria attacks is not predictive of the level of protective immunity.
The main goal of the current malaria control strategies is to prevent malaria mortality by diagnosing and treating clinical manifestations of the disease as early as possible. 1 This …
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