Authors
Jean-Louis A Ndiaye, Babacar Faye, Ali Gueye, Roger Tine, Daouda Ndiaye, Corinne Tchania, Ibrahima Ndiaye, Aichatou Barry, Badara Cissé, Valérie Lameyre, Oumar Gaye
Publication date
2011/12
Journal
Malaria journal
Volume
10
Pages
1-12
Publisher
BioMed Central
Description
Background
The use of artemisinin-based combination therapy (ACT) is currently recommended for treating uncomplicated malaria. The objective was to assess the efficacy and safety of repeated administrations of two fixed-dose presentations of ACT - artesunate plus amodiaquine (ASAQ) and artemether-lumefantrine (AL) - in subsequent episodes of Plasmodium falciparum malaria.
Methods
A randomized comparative study was conducted in a rural community of central Senegal from August 2007 to January 2009. Children and adults with uncomplicated P. falciparum malaria were randomized to receive open-label ASAQ once daily or AL twice daily for three days. Drug doses were given according to body weight. Treatments for first episodes were supervised. For subsequent episodes, only the first intake of study drug was supervised. ECGs and …
Scholar articles
JLA Ndiaye, B Faye, A Gueye, R Tine, D Ndiaye… - Malaria journal, 2011