Authors
Caroline Ogwang, Domtila Kimani, Nick J Edwards, Rachel Roberts, Jedidah Mwacharo, Georgina Bowyer, Carly Bliss, Susanne H Hodgson, Patricia Njuguna, Nicola K Viebig, Alfredo Nicosia, Evelyn Gitau, Sandy Douglas, Joe Illingworth, Kevin Marsh, Alison Lawrie, Egeruan B Imoukhuede, Katie Ewer, Britta C Urban, Adrian V S. Hill, Philip Bejon, MVVC group, Odile Leroy, Badara Cisse, Sodiomon Sirima, Kalifa Bojang, Georgina Murphy, Henry Karanja, Lydiah Nyamako, Simone De Cassan, Ken Awuondo, Dominic Kwiatkowski, Kirk Rockett, Sarah Gilbert, Nicholas Anagnostou, Peninah Soipei, Judy Peshu, Ines Petersen, Brian Mutinda, Naomi Waithira, Mahfudh Bashraheil, Jimmy Shangala, Sarah Moyle, Eleanor Berrie, Geoffrey Targett, Mahamadou Thera, Paul Milligan, Bernhards Ogutu, Anthony Etyang
Publication date
2015/5/6
Journal
Science translational medicine
Volume
7
Issue
286
Pages
286re5-286re5
Publisher
American Association for the Advancement of Science
Description
Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-induced T cells, but no subunit vaccination approach based on cellular immunity has shown efficacy in field studies. We randomly allocated 121 healthy adult male volunteers in Kilifi, Kenya, to vaccination with the recombinant viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia Ankara (MVA), both encoding the malaria peptide sequence ME-TRAP (the multiple epitope string and thrombospondin-related adhesion protein), or to vaccination with rabies vaccine as a control. We gave antimalarials to clear parasitemia and conducted PCR (polymerase chain reaction) analysis on blood samples three times a week to identify infection with the malaria parasite Plasmodium falciparum. On Cox regression, vaccination reduced the risk of infection by 67% [95% confidence interval (CI), 33 to 83%; P = 0.002] during 8 …
Scholar articles
C Ogwang, D Kimani, NJ Edwards, R Roberts… - Science translational medicine, 2015