Authors
Joshua A Shapiro, Krutika S Gaonkar, Stephanie J Spielman, Candace L Savonen, Chante J Bethell, Run Jin, Komal S Rathi, Yuankun Zhu, Laura E Egolf, Bailey K Farrow, Daniel P Miller, Yang Yang, Tejaswi Koganti, Nighat Noureen, Mateusz P Koptyra, Nhat Duong, Mariarita Santi, Jung Kim, Shannon Robins, Phillip B Storm, Stephen C Mack, Jena V Lilly, Hongbo M Xie, Payal Jain, Pichai Raman, Brian R Rood, Rishi R Lulla, Javad Nazarian, Adam A Kraya, Zalman Vaksman, Allison P Heath, Cassie Kline, Laura Scolaro, Angela N Viaene, Xiaoyan Huang, Gregory P Way, Steven M Foltz, Bo Zhang, Anna R Poetsch, Sabine Mueller, Brian M Ennis, Michael Prados, Sharon J Diskin, Siyuan Zheng, Yiran Guo, Shrivats Kannan, Angela J Waanders, Ashley S Margol, Meen Chul Kim, Derek Hanson, Nicholas Van Kuren, Jessica Wong, Rebecca S Kaufman, Noel Coleman, Christopher Blackden, Kristina A Cole, Jennifer L Mason, Peter J Madsen, Carl J Koschmann, Douglas R Stewart, Eric Wafula, Miguel A Brown, Adam C Resnick, Casey S Greene, Jo Lynne Rokita, Jaclyn N Taroni
Publication date
2023/7/12
Journal
Cell genomics
Volume
3
Issue
7
Publisher
Elsevier
Description
Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, the Children's Brain Tumor Network (CBTN) and Pacific Pediatric Neuro-Oncology Consortium (PNOC) created a systematic process for tumor biobanking, model generation, and sequencing with immediate access to harmonized data. We leverage these data to establish OpenPBTA, an open collaborative project with over 40 scalable analysis modules that genomically characterize 1,074 pediatric brain tumors. Transcriptomic classification reveals universal TP53 dysregulation in mismatch repair-deficient hypermutant high-grade gliomas and TP53 loss as a significant marker for poor overall survival in ependymomas and H3 K28-mutant diffuse midline gliomas. Already being actively applied to other pediatric …
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