Authors
Kim LR Brouwer, Lauren M Aleksunes, Barbara Brandys, George P Giacoia, Gregory Knipp, Viera Lukacova, Bernd Meibohm, Sanjay K Nigam, Michael Rieder, Saskia N de Wildt, Pediatric Transporter Working Group, Susan Abdel‐Rahman, Lauren M Aleksunse, Sharyn D Baker, Michael B Bolger, Barbara Brandys, Kim LR Brouwer, Kevin T Bush, Barbara Clancy, John M DeSesso, Jeffery Fisher, Tsuyoshi Fukuda, George P Giacoia, Richard Kim, Gregory Knipp, Gideon Koren, Grace S Lee, J Steven Leeder, Viera Lukacova, Bernd Meibohm, Tomoyuki Mizuno, Miriam G Mooij, Sanjay K Nigam, Michael Rieder, Matthias Schwab, Evita van de Steeg, Margaret MS Thomson, Aksana Vasilyeva, Alexander A Vinks, Saskia N de Wildt, Wei Wu
Publication date
2015/9
Source
Clinical Pharmacology & Therapeutics
Volume
98
Issue
3
Pages
266-287
Description
The critical importance of membrane‐bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
Scholar articles
KLR Brouwer, LM Aleksunes, B Brandys, GP Giacoia… - Clinical Pharmacology & Therapeutics, 2015