Authors
Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Brian A Schmidt, Timothy D Carroll, Kourtney D Weaver, Justin C Smith, Anil Verma, Jesse D Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J Olstad, J Rachel Reader, Zhong-Min Ma, Nancy K Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O’Connor, Stephen J McSorley, John H Morrison, Nam K Tran, Graham Simmons, Michael P Busch, Pamela A Kozlowski, Koen KA Van Rompay, Christopher J Miller, Smita S Iyer
Publication date
2021/1/22
Journal
Nature communications
Volume
12
Issue
1
Pages
541
Publisher
Nature Publishing Group UK
Description
CD4 T follicular helper (Tfh) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates Tfh cells and stimulates the germinal center (GC) response is an important question as we investigate vaccine induced immunity against COVID-19. Here, we report that SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating Tfh cells with a Th1 profile in peripheral blood. CD4 helper cell responses skewed predominantly toward a Th1 response in blood, lung, and lymph nodes. SARS-CoV-2 Infection induced GC Tfh cells specific for the SARS-CoV-2 spike and nucleocapsid proteins, and a corresponding early appearance of antiviral serum IgG antibodies. Collectively, the data …
Total citations
Scholar articles
Y Shaan Lakshmanappa, SR Elizaldi, JW Roh… - Nature communications, 2021