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The water-energy-food (WEF) nexus is the subject of much research focusing on different aspects, a wide range of issues, and development of a variety of models and tools. This study takes a different approach by developing a holistic framework that concentrates on the spatial elements of continuity and change associated with WEF transition on national, regional, and international scale. The study also investigates the interconnected challenges that could affect these resources and the actions and polices that should be taken on different geographical scales to address these challenges. The results can help practitioners and policy makers gain a clearer understanding of the state of the knowledge when performing WEF nexus assessments at different geographical scales.