Authors
Ki Chang Ahn, Bin Zhao, Jiangang Chen, Gennady Cherednichenko, Enio Sanmarti, Michael S Denison, Bill Lasley, Isaac N Pessah, Dietmar Kültz, Daniel PY Chang, Shirley J Gee, Bruce D Hammock
Publication date
2008/9
Journal
Environmental health perspectives
Volume
116
Issue
9
Pages
1203-1210
Publisher
National Institute of Environmental Health Sciences
Description
Background
Concerns have been raised about the biological and toxicologic effects of the antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects.
Objectives
In this study, we assessed the activity of TCC, its analogs, and TCS in in vitro nuclear-receptor–responsive and calcium signaling bioassays.
Materials and methods
We determined the biological activities of the compounds in in vitro, cell-based, and nuclear-receptor–responsive bioassays for receptors for aryl hydrocarbon (AhR), estrogen (ER), androgen (AR), and ryanodine (RyR1).
Results
Some carbanilide compounds, including TCC (1–10 μM), enhanced estradiol (E2)-dependent or testosterone-dependent activation of ER- and AR-responsive gene expression up to 2.5-fold but exhibited little or no agonistic activity …
Total citations
Scholar articles
KC Ahn, B Zhao, J Chen, G Cherednichenko… - Environmental health perspectives, 2008