Authors
Ian G McKeith, Dennis W Dickson, J Lowe, M Emre, JT O'brien, H Feldman, J Cummings, JE Duda, C Lippa, EK Perry, D Aarsland, H Arai, CG Ballard, B Boeve, DJ Burn, D Costa, TMDP Del Ser, B Dubois, D Galasko, SFRCPC Gauthier, CG Goetz, EMDP Gomez-Tortosa, G Halliday, LA Hansen, J Hardy, T Iwatsubo, RN Kalaria, D Kaufer, RA Kenny, A Korczyn, K Kosaka, VMY Lee, A Lees, I Litvan, Elisabet Londos, OL Lopez, SMDP Minoshima, Y Mizuno, JA Molina, EB Mukaetova-Ladinska, FMDP Pasquier, RH Perry, Joerg B Schulz, John Q Trojanowski, Masahito Yamada
Publication date
2005/12/27
Source
Neurology
Volume
65
Issue
12
Pages
1863-1872
Publisher
Lippincott Williams & Wilkins
Description
The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density …
Total citations
Scholar articles
IG McKeith, DW Dickson, J Lowe, M Emre, JT O'brien… - Neurology, 2005
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium*
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IG McKeith, DW Dickson, J Lowe, M Emre, JT O'Brien… - Third report of the DLB consortium. Neurology, 2005