Authors
Laura Tedesco, Alessandra Valerio, Cristina Cervino, Annalisa Cardile, Claudio Pagano, Roberto Vettor, Renato Pasquali, Michele O Carruba, Giovanni Marsicano, Beat Lutz, Uberto Pagotto, Enzo Nisoli
Publication date
2008/8/1
Journal
Diabetes
Volume
57
Issue
8
Pages
2028-2036
Publisher
American Diabetes Association
Description
OBJECTIVE—Cannabinoid type 1 (CB1) receptor blockade decreases body weight and adiposity in obese subjects; however, the underlying mechanism is not yet fully understood. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) induces mitochondrial biogenesis and function in adipocytes. This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes.
RESEARCH DESIGN AND METHODS—We examined the effects on eNOS and mitochondrial biogenesis of selective pharmacological blockade of CB1 receptors by SR141716 (rimonabant) in mouse primary white adipocytes. We also examined eNOS expression and mitochondrial biogenesis in white adipose tissue (WAT) and isolated mature white adipocytes of CB1 receptor–deficient (CB1−/−) and chronically SR141716-treated mice on either …
Total citations
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Scholar articles
L Tedesco, A Valerio, C Cervino, A Cardile, C Pagano… - Diabetes, 2008