Authors
Alexis Elias Malavazos, Angelica Di Vincenzo, Gianluca Iacobellis, Sara Basilico, Carola Dubini, Lelio Morricone, Lorenzo Menicanti, Tonia Luca, Antonio Giordano, Sergio Castorina, Michele Carruba, Enzo Nisoli, Stefano Del Prato, Saverio Cinti
Publication date
2022/10
Journal
Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity
Volume
27
Issue
7
Pages
2905-2910
Publisher
Springer International Publishing
Description
Purpose
The visceral fat of patients affected by abdominal obesity is inflamed, and the main histopathologic feature is the high density of crown-like structures (CLS). Epicardial adipose tissue (EAT) is a visceral fat of paramount importance for its relationships with coronary vessels and myocardium. Its inflammation in patients with abdominal obesity could be of clinical relevance, but histopathological studies on CLS density in EAT are lacking. This study aimed to assess the histopathology of EAT biopsies obtained from patients undergoing open-heart surgery.
Methods
We collected EAT biopsies from 10 patients undergoing open-heart surgery for elective coronary artery bypass grafting (CABG) (n = 5) or valvular replacement (VR) (n = 5). Biopsies were treated for light microscopy and immunohistochemistry. We quantify the CLS density in each EAT sample.
Results
Despite all patients having abdominal obesity, in …
Total citations
Scholar articles
AE Malavazos, A Di Vincenzo, G Iacobellis, S Basilico… - Eating and Weight Disorders-Studies on Anorexia …, 2022