Authors
Thomas Powles, Ignacio Durán, Michiel S Van der Heijden, Yohann Loriot, Nicholas J Vogelzang, Ugo De Giorgi, Stéphane Oudard, Margitta M Retz, Daniel Castellano, Aristotelis Bamias, Aude Fléchon, Gwenaëlle Gravis, Syed Hussain, Toshimi Takano, Ning Leng, Edward E Kadel, Romain Banchereau, Priti S Hegde, Sanjeev Mariathasan, Na Cui, Xiaodong Shen, Christina L Derleth, Marjorie C Green, Alain Ravaud
Publication date
2018/2/24
Journal
The Lancet
Volume
391
Issue
10122
Pages
748-757
Publisher
Elsevier
Description
Background
Few options exist for patients with locally advanced or metastatic urothelial carcinoma after progression with platinum-based chemotherapy. We aimed to assess the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [PD-L1]) versus chemotherapy in this patient population.
Methods
We conducted this multicentre, open-label, phase 3 randomised controlled trial (IMvigor211) at 217 academic medical centres and community oncology practices mainly in Europe, North America, and the Asia-Pacific region. Patients (aged ≥18 years) with metastatic urothelial carcinoma who had progressed after platinum-based chemotherapy were randomly assigned (1:1), via an interactive voice and web response system with a permuted block design (block size of four), to receive atezolizumab 1200 mg or chemotherapy (physician's choice: vinflunine 320 mg/m2, paclitaxel 175 mg/m2, or 75 mg/m2 …
Scholar articles
T Powles, I Durán, MS Van der Heijden, Y Loriot… - The Lancet, 2018