Authors
Francisco Gama, Stefania Rosmini, Steve Bandula, Kush P Patel, Paolo Massa, Catalina Tobon-Gomez, Karolin Ecke, Tyler Stroud, Mark Condron, George D Thornton, Jonathan B Bennett, Ashutosh Wechelakar, Julian D Gillmore, Carol Whelan, Helen Lachmann, Stuart A Taylor, Francesca Pugliese, Marianna Fontana, James C Moon, Philip N Hawkins, Thomas A Treibel
Publication date
2022/12/1
Journal
Cardiovascular Imaging
Volume
15
Issue
12
Pages
2082-2094
Publisher
American College of Cardiology Foundation
Description
Background
Light chain (AL) and transthyretin (ATTR) amyloid fibrils are deposited in the extracellular space of the myocardium, resulting in heart failure and premature mortality. Extracellular expansion can be quantified by computed tomography, offering a rapid, cheaper, and more practical alternative to cardiac magnetic resonance, especially among patients with cardiac devices or on renal dialysis.
Objectives
This study sought to investigate the association of extracellular volume fraction by computed tomography (ECVCT), myocardial remodeling, and mortality in patients with systemic amyloidosis.
Methods
Patients with confirmed systemic amyloidosis and varying degrees of cardiac involvement underwent electrocardiography-gated cardiac computed tomography. Whole heart and septal ECVCT was analyzed. All patients also underwent clinical assessment, electrocardiography, echocardiography, serum …
Total citations
Scholar articles
F Gama, S Rosmini, S Bandula, KP Patel, P Massa… - Cardiovascular Imaging, 2022