Authors
Perrine Janiaud, Cathrine Axfors, Andreas M Schmitt, Viktoria Gloy, Fahim Ebrahimi, Matthias Hepprich, Emily R Smith, Noah A Haber, Nina Khanna, David Moher, Steven N Goodman, John PA Ioannidis, Lars G Hemkens
Publication date
2021/3/23
Source
Jama
Volume
325
Issue
12
Pages
1185-1195
Publisher
American Medical Association
Description
Importance
Convalescent plasma is a proposed treatment for COVID-19.
Objective
To assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of randomized clinical trials (RCTs).
Data Sources
PubMed, the Cochrane COVID-19 trial registry, and the Living Overview of Evidence platform were searched until January 29, 2021.
Study Selection
The RCTs selected compared any type of convalescent plasma vs placebo or standard of care for patients with confirmed or suspected COVID-19 in any treatment setting.
Data Extraction and Synthesis
Two reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The primary analysis included peer-reviewed publications of RCTs only, whereas the secondary analysis …
Scholar articles
P Janiaud, C Axfors, AM Schmitt, V Gloy, F Ebrahimi… - Jama, 2021