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Two experiments were conducted to examine effects of muscle fatigue on motor-unit synchronization of quadriceps muscles (rectus femoris, vastus medialis, vastus lateralis) within and between legs. We expected muscle fatigue to result in an increased common drive to different motor units of synergists within a leg and, hence, to increased synchronization, i.e., an increased coherence between corresponding surface EMGs. We further expected fatigue-related motor overflow to cause motor-unit synchronization of homologous muscles of both legs, although to a lesser extent than for synergists within a leg. In the first experiment, different levels of fatigue were induced by varying posture (knee angle), whereas in the second experiment fatigue was induced in a fixed posture by instructing participants to produce different force levels. EMG coherence was found in two distinct frequency bands (6–11 and 13–18Hz) and …