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Objective:

Granulocytopenia frequently occurs in alcohol abusers with severe bacterial infection, which strongly correlates with poor clinical outcome. Knowledge of the molecular mechanisms underlying the granulopoietic response to bacterial infection remains limited. This study investigated the involvement of stem cell antigen-1 expression by granulocyte lineage-committed progenitors in the granulopoietic response to septicemia and how alcohol affected this response.

Design:

Laboratory investigation.

Setting:

University laboratory.

Subjects:

Male Balb/c mice.

Interventions:

Thirty mins after intraperitoneal injection of alcohol (20% ethanol in saline at 5 g of ethanol/kg) or saline, mice received an intravenous Escherichia coli challenge.

Measurements and Main Results:

E. coli septicemia activated stem cell antigen-1 expression by marrow immature granulocyte differentiation antigen-1 lo precursors which correlated with …