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[Objective] The present study was conducted to investigate the relationship between body weight (BW) of fetus and biochemical parameters of fetal liquid in Huanjiang mini-pigs in order to illuminate the genesis mechanism, and approach prevention and cure methods of intrauterine growth retardation (IUGR).[Method] Seven female mini-pigs with a live BW of 35-40 kg were chosen in this study and raised in seven pens of one pig. At the end of a 45-day feeding period after serviced, the sows were killed by bloodletting of arteria carotis, and the BW of fetus and the weight of placenta and womb were got. The amniotic fluid, allantonic fluid and placenta were collected from two fetus with minimal BW or maximal BW per sow, respectively, for analysis.[Result] Results showed that the BW of fetus, placenta weight, womb weight, volume of amniotic fluid plus allantonic fluid in fetus with minimal BW were lower by 23%, 62 …