Authors
SMART Study Group*
Publication date
2008/9/2
Journal
Annals of internal medicine
Volume
149
Issue
5
Pages
289-299
Publisher
American College of Physicians
Description
Background
Episodic use of antiretroviral therapy guided by CD4+ cell counts is inferior to continuous antiretroviral therapy.
Objective
To determine whether reinitiating continuous antiretroviral therapy in patients who received episodic treatment reduces excess risk for opportunistic disease or death.
Design
Randomized, controlled trial.
Setting
Sites in 33 countries.
Patients
5472 HIV-infected individuals with CD4+ cell counts greater than 0.350 × 109 cells/L enrolled from January 2002 to January 2006.
Intervention
Episodic or continuous antiretroviral therapy initially, followed by continuous therapy in participants previously assigned to episodic treatment.
Measurements
Opportunistic disease or death was the …
Total citations
Scholar articles
SMART Study Group* - Annals of internal medicine, 2008