Authors
Thorsten Hoppe, Michael Rape, Stefan Jentsch
Publication date
2001/6/1
Source
Current opinion in cell biology
Volume
13
Issue
3
Pages
344-348
Publisher
Elsevier Current Trends
Description
Regulated nuclear transport of transcription factors from cytoplasmic pools is a major route by which eukaryotes control gene expression. Exquisite examples are transcription factors that are kept in a dormant state in the cytosol by membrane anchors; such proteins are released from membranes by proteolytic cleavage, which enables these transcription factors to enter the nucleus. Cleavage can be mediated either by regulated intramembrane proteolysis (RIP) catalysed by specific membrane-bound proteases or by regulated ubiquitin/proteasome-dependent processing (RUP). In both cases processing can be controlled by cues that originate at or in the vicinity of the membrane.
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T Hoppe, M Rape, S Jentsch - Current opinion in cell biology, 2001