Authors
Daniel B Kay, Helmet T Karim, Adriane M Soehner, Brant P Hasler, Kristine A Wilckens, Jeffrey A James, Howard J Aizenstein, Julie C Price, Bedda L Rosario, David J Kupfer, Anne Germain, Martica H Hall, Peter L Franzen, Eric A Nofzinger, Daniel J Buysse
Publication date
2016/10/1
Journal
Sleep
Volume
39
Issue
10
Pages
1779-1794
Publisher
Oxford University Press
Description
Study Objectives
The neurobiological mechanisms of insomnia may involve altered patterns of activation across sleep-wake states in brain regions associated with cognition, self-referential processes, affect, and sleep-wake promotion. The objective of this study was to compare relative regional cerebral metabolic rate for glucose (rCMRglc) in these brain regions across wake and nonrapid eye movement (NREM) sleep states in patients with primary insomnia (PI) and good sleeper controls (GS).
Methods
Participants included 44 PI and 40 GS matched for age (mean = 37 y old, range 21–60), sex, and race. We conducted [18F]fluoro-2-deoxy-d-glucose positron emission tomography scans in PI and GS during both morning wakefulness and NREM sleep at night. Repeated measures analysis of variance was used to test for group (PI vs. GS) by state (wake vs. NREM sleep …
Scholar articles
DB Kay, HT Karim, AM Soehner, BP Hasler… - Sleep, 2016