Authors
Caroline J Jolley, Yuan-Ming Luo, Joerg Steier, Charles Reilly, John Seymour, Alan Lunt, Katie Ward, Gerrard F Rafferty, Michael I Polkey, John Moxham
Publication date
2009/2/1
Journal
European Respiratory Journal
Volume
33
Issue
2
Pages
289-297
Publisher
European Respiratory Society
Description
The aim of the present study was to use the diaphragm electromyogram (EMGdi) to compare levels of neural respiratory drive (NRD) in a cohort of healthy subjects and chronic obstructive pulmonary disease (COPD) patients, and to investigate the relationship between NRD and pulmonary function in COPD.
EMGdi was recorded at rest and normalised to peak EMGdi recorded during maximum inspiratory manoeuvres (EMGdi % max) in 100 healthy subjects and 30 patients with COPD, using a multipair oesophageal electrode. EMGdi was normalised to the amplitude of the diaphragm compound muscle action potential (CMAPdi,MS) in 64 healthy subjects.
The mean±sd EMGdi % max was 9.0±3.4% in healthy subjects and 27.9±9.9% in COPD patients, and correlated with percentage predicted forced expiratory volume in one second, vital capacity and inspiratory capacity in patients. EMGdi % max was higher …
Total citations
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Scholar articles
CJ Jolley, YM Luo, J Steier, C Reilly, J Seymour, A Lunt… - European Respiratory Journal, 2009