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In-region location verification (IRLV) aims at verifying whether a user is inside a region of interest (ROI). In wireless networks, IRLV can exploit the features of the channel between the user and a set of trusted access points. In practice, the channel feature statistics is not available and we resort to machine learning (ML) solutions for IRLV. We first show that solutions based on either neural networks (NNs) or support vector machines (SVMs) with typical loss functions are Neyman-Pearson (N-P)-optimal at learning convergence for sufficiently complex learning machines and large training datasets. For a finite training, ML solutions are more accurate than the N-P test based on estimated channel statistics. Then, as estimating channel features outside the ROI may be difficult, we consider one-class classifiers, namely auto-encoder NNs and one-class SVMs which, however, are not equivalent to the generalized likelihood …