Authors
ENCODE Project Consortium Overall coordination (data analysis coordination) Dunham Ian 2 Kundaje Anshul 3 81 82 82, Writing group Bernstein Bradley E. 7 34 Birney Ewan Dunham Ian Green Eric D. 35 Gunter Chris 15 Snyder Michael 13, Genome Institute of Singapore group (data production and analysis) Li Guoliang Sandhu Kuljeet Singh Zheng Meizhen 48 Wang Ping 48 Luo Oscar J. Shahab Atif Fullwood Melissa J. Ruan Xiaoan Ruan Yijun, Lawrence Berkeley National Laboratory group (targeted experimental validation) Blow Matthew J. 55 Visel Axel 55 56 Pennachio Len A. 55 56, NHGRI groups (data production and analysis) Elnitski Laura Margulies Elliott H. Parker Stephen CJ Petrykowska Hanna M. 38, University of Albany SUNY group (data production and analysis) Tenenbaum Scott A. Penalva Luiz O. 69 Doyle Francis, University of Massachusetts Medical School Bioinformatics group (data production and analysis) Weng Zhiping Whitfield Troy W. Wang Jie Collins Patrick J. Aldred Shelley F. Trinklein Nathan D. Partridge E. Christopher Myers Richard M., University of Massachusetts Medical School Genome Folding group (data production and analysis) Dekker Job Jain Gaurav 12 Lajoie Bryan R. Sanyal Amartya
Publication date
2012/9/6
Journal
Nature
Volume
489
Issue
7414
Pages
57-74
Publisher
Nature Publishing Group UK
Description
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is …
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Scholar articles
… Project Consortium Overall coordination (data analysis … - Nature, 2012