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In this doctoral thesis, I aim to step further beyond state-of-the-art towards the development of a cortical neuroprosthesis for the blind. Currently, a fully working visual cortical neuroprosthesis able to help blind people to recover a form of vision is still a challenging ongoing project, although strong efforts are being made by research groups all over the world. This work is situated at the conjunction between neuroscience, neural engineering, and artificial intelligence.