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To the Editor: A reference range for cerebrospinal fluid (CSF) opening pressure in children undergoing diagnostic lumbar puncture has not been established.¹ The influence of age, body-mass index (BMI), and depth of sedation on opening pressure in children is also uncertain.²

We conducted a 2-year, single-center prospective study of CSF opening pressure in children undergoing lumbar puncture as part of their routine clinical care. Our objective was to establish a useful, clinically relevant reference range for opening pressure and a threshold value for abnormally elevated opening pressure (in the 90th percentile or higher, defined a priori). Our reference group consisted . . .