Authors
Ron Keren, Samir S Shah, Rajendu Srivastava, Shawn Rangel, Michael Bendel-Stenzel, Nada Harik, John Hartley, Michelle Lopez, Luis Seguias, Joel Tieder, Matthew Bryan, Wu Gong, Matt Hall, Russell Localio, Xianqun Luan, Rachel deBerardinis, Allison Parker, Pediatric Research in Inpatient Settings Network
Publication date
2015/2/1
Journal
JAMA pediatrics
Volume
169
Issue
2
Pages
120-128
Publisher
American Medical Association
Description
Importance
Postdischarge treatment of acute osteomyelitis in children requires weeks of antibiotic therapy, which can be administered orally or intravenously via a peripherally inserted central catheter (PICC). The catheters carry a risk for serious complications, but limited evidence exists on the effectiveness of oral therapy.
Objective
To compare the effectiveness and adverse outcomes of postdischarge antibiotic therapy administered via the PICC or the oral route.
Design, Setting, and Participants
We performed a retrospective cohort study comparing PICC and oral therapy for the treatment of acute osteomyelitis. Among children hospitalized from January 1, 2009, through December 31, 2012, at 36 participating children’s hospitals, we used discharge codes to identify potentially eligible participants. Results of medical record review confirmed eligibility and defined treatment group allocation and study outcomes. We …
Scholar articles
R Keren, SS Shah, R Srivastava, S Rangel… - JAMA pediatrics, 2015