Authors
Arielle Marks‐Anglin, Chongliang Luo, Jin Piao, Mary Beth Connolly Gibbons, Christopher H Schmid, Jing Ning, Yong Chen
Publication date
2022/6
Journal
Biometrics
Volume
78
Issue
2
Pages
754-765
Description
Systematic reviews and meta‐analyses synthesize results from well‐conducted studies to optimize healthcare decision‐making. Network meta‐analysis (NMA) is particularly useful for improving precision, drawing new comparisons, and ranking multiple interventions. However, recommendations can be misled if published results are a selective sample of what has been collected by trialists, particularly when publication status is related to the significance of the findings. Unfortunately, the missing‐not‐at‐random nature of this problem and the numerous parameters involved in modeling NMAs pose unique computational challenges to quantifying and correcting for publication bias, such that sensitivity analysis is used in practice. Motivated by this important methodological gap, we developed a novel and stable expectation‐maximization (EM) algorithm to correct for publication bias in the network setting. We validate …
Total citations
2023202442