Authors
CE Geyer Jr, JE Garber, RD Gelber, Greg Yothers, M Taboada, L Ross, P Rastogi, K Cui, A Arahmani, G Aktan, Anne C Armstrong, M Arnedos, J Balmaña, J Bergh, J Bliss, S Delaloge, SM Domchek, A Eisen, F Elsafy, LE Fein, A Fielding, JM Ford, S Friedman, KA Gelmon, L Gianni, M Gnant, SJ Hollingsworth, S-A Im, A Jager, Ó Þ Jóhannsson, SR Lakhani, W Janni, B Linderholm, T-W Liu, N Loman, L Korde, S Loibl, PC Lucas, F Marmé, E Martinez de Dueñas, R McConnell, K-A Phillips, M Piccart, G Rossi, R Schmutzler, Elżbieta Senkus, Z Shao, P Sharma, CF Singer, T Španić, E Stickeler, M Toi, TA Traina, G Viale, G Zoppoli, YH Park, R Yerushalmi, H Yang, D Pang, KH Jung, A Mailliez, Z Fan, Isabelle Tennevet, J Zhang, T Nagy, GS Sonke, Q Sun, M Parton, MA Colleoni, M Schmidt, AM Brufsky, Wajeeha Razaq, B Kaufman, D Cameron, C Campbell, ANJ Tutt, Paul Sevelda, Ferdinand Haslbauer, Monika Penzinger, Leopold Öhler, Christoph Tinchon, Richard Greil, Sonja Heibl, Rupert Bartsch, Viktor Wette, Christian F Singer, Claudia Pasterk, Ruth Helfgott, Gunda Pristauz-Telsnigg, Herbert Stöger, Angsar Weltermann, Daniel Egle, Irene Thiel, David Fuchs, Holger Rumpold, Kathrin Strasser-Weippl, Beate Rautenberg, Volkmar Müller, Marcus Schmidt, Stefan Paepke, Mustafa Aydogdu, Christoph Thomssen, Joachim Rom, Christine Mau, Peter Fasching, Uwe-Jochen Göhring, Thorsten Kühn, Stefanie Noeding, Sherko Kümmel, John Hackmann, Elmar Stickeler, Abhishek Joshi, Joanna Dewar, Michael Friedlander, Kelly-Anne Phillips, Yoland Antill, Natasha Woodward, Ehtesham Abdi, Susan Tiley, Mathew George, David Boadle, Annabel Goodwin, Andre van der Westhuizen, George Kannourakis, Nicholas Murray, Nicole McCarthy, Judith Kroep, Maaike de Boer, Joan Heijns, Agnes Jager, Franciscus Erdkamp, Sandra Bakker, Gabe S Sonke, Amer Sami, John Mackey, Catherine Prady, Andrea Eisen, Christine Desbiens, Erica Patocskai, Cristiano Ferrario, Karen Gelmon, Louise Bordeleau, Haji Chalchal, Saroj Niraula, Elżbieta Senkus, François Duhoux, Randal d’Hondt, Sylvie Luce, Daphné t’Kint de Roodenbeke, Konstantinos Papadimitriou
Publication date
2022/12/1
Journal
Annals of oncology
Volume
33
Issue
12
Pages
1250-1268
Publisher
Elsevier
Description
Background
The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewer deaths than the placebo group, but the difference did not reach statistical significance for overall survival (OS). We now report the pre-specified second IA of OS with updates of IDFS, DDFS, and safety.
Patients and methods
One thousand eight hundred and thirty-six patients were randomly assigned to olaparib or …
Total citations
Scholar articles
CE Geyer Jr, JE Garber, RD Gelber, G Yothers… - Annals of oncology, 2022